Candesar tablets 8mg are used to treat essential hypertension, which is high blood pressure when at rest, with usually no obvious and identifiable cause. Although there are usually no other symptoms, high blood pressure increases risk of cardiovascular disease and if uncontrolled can cause kidney damage, stroke, heart attack and heart failure. Candesar-8 lowers blood pressure to normal resting levels, which helps the heart to cope better; increasing life expectancy and reducing the risk of cardiovascular disease and end organ damage. Candesar-8 can be used alone as monotherapy or in combination with other antihypertensive medication such as diuretics (water tablets). Candesar-8 is also used to treat heart failure (the heart muscles are weakened and cannot pump efficiently) and left ventricular systolic dysfunction (when the left ventricle cannot pump out blood properly) to reduce mortality and hospitalisation due to heart failure; also to improve symptoms, including breathlessness and oedema (fluid retention in the tissues).
Candesar tablets 8mg contain candesartan, an angiotensin II receptor blocker (ARB), which acts by blocking the binding of the hormone angiotensin II to its receptor in a variety of tissues, including vascular smooth muscle (blood vessel walls) and kidney cells. Angiotensin II is a naturally produced hormone that has several actions involved in regulating blood pressure, which is the force needed to pump blood around the body; as well as regulating fluid balance, the amount of water removed from the blood by the kidneys. Angiotensin II causes salt (sodium and potassium) and water retention by the kidneys, and causes blood vessels to constrict (narrow); this increases blood volume while at the same time reducing blood vessel volume, which increases blood pressure. Candesartan in Candesar-8 blocks the binding of Angiotensin II to its receptor, preventing its pressor actions (blood pressure increasing) resulting in dilation (widening) of blood vessel and increased amount of salt and water removed by the kidneys into the urine, which lowers blood pressure. Reducing blood pressure reduces the workload on the heart, which reduces risk of cardiovascular disease; as well improving symptoms of heart failure. Blood pressure is reduced within 2 hours of taking Candesar-8 and you should achieve maximum blood pressure reduction within 4 weeks.
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