Carloc tablets (also known as Coreg in the US) are used to treat a variety of conditions of the cardiovascular system. These include, control of hypertension (high blood pressure) by lowering blood pressure to reduce the risk of complications such as stroke and heart attack; management of stable angina (chest pain) in patients with heart disease, where there is not enough oxygen getting to the heart; chronic but stable heart failure, in conjunction with other medications, by helping weakened heart muscles pump more efficiently. Carloc 12.5 work through a common mechanism in several different body systems to manage the condition and relieve symptoms by reducing heart rate (pulse), workload on the heart (force needed to pump) and oxygen demand by the heart, which increases blood flow and lowers blood pressure.
Carloc tablets (also known as Coreg in the US) contain carvedilol, which is a non-selective beta-blocker and acts as a beta1 and beta2 receptor antagonist, with some action as an alpha-receptor antagogist. Carvedilol in Carloc tablets 12.5mg works by blocking the action of chemicals called catecholamines, such as adrenaline and noradrenaline (epinephrine and nor epinephrine), which are released by the adrenal glands in response to nerve stimulation during physical and mental stress. Adrenaline works by stimulating beta-receptors in the heart, which increases heart rate and causes constriction (narrowing) of blood vessels. Carvedilol in Carloc tablets 12.5mg blocks the beta-receptors in the heart, to slow heart rate and reduce the force needed to pump blood around the body, which means that the heart needs less oxygen. This action relieves the pain of angina which is caused by increased workload and lack of oxygen to the heart on exertion. Carvedilol in Carloc tablets 12.5mg also blocks alpha-receptors found in peripheral blood vessel walls, and this causes them to relax and widen (vasodilation), reducing the resistance to blood flow. The combined action of alpha and beta blockade by Carloc 12.5 reduces the force needed by the heart to pump blood and increases blood flow and oxygen to the heart, while at the same time reducing resistance to blood circulating in peripheral vessels by causing vasodilation, which helps lower blood pressure; as well as helping the heart pump more efficiently, thereby reducing feelings of breathlessness on exertion due to weakened heart muscles as in congestive heart failure.
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