Hyzaar tablets are a fixed dose combination medication used to treat hypertension, which is high blood pressure when at rest, particularly with left ventricular hypertrophy, which is when the heart works harder due to high blood pressure, causing thickening of the left pumping chamber. Hyzaar tablets 100/12.5 are used when blood pressure cannot be controlled by a single medication. Although there are usually no other symptoms, high blood pressure increases risk of cardiovascular disease and Hyzaar tablets reduce the risk of stroke and heart attack, by lowering blood pressure to normal resting levels, which helps the heart to cope better so increasing life expectancy.
Hyzaar tablets contain a fixed dose combination of two medications that work together to reduce blood pressure, in a way that is more effective that if each drug is used alone. Losartan is an angiotensin II receptor blocker (ARB), which acts by blocking the binding of the hormone angiotensin II to its receptor in a variety of tissues including vascular smooth muscle (blood vessel walls) and kidney cells. Angiotensin II is a naturally produced hormone that has several actions involved in regulating blood pressure, which is the force needed to pump blood around the body, as well as fluid balance, the amount of water removed from the blood by the kidneys. Angiotensin II causes salt (sodium and potassium) and water retention by the kidneys, and causes blood vessels to constrict (narrow); this increases blood volume while at the same time reducing blood vessel volume, which increases blood pressure. Losartan in Hyzaar tablets 100/12.5 mg blocks the binding of Angiotensin II to its receptor, preventing its pressor actions (blood pressure increasing) resulting in dilation (widening) of blood vessel and increased amount of salt and water removed by the kidneys into the urine, which lowers blood pressure. Hydrochlorothiazide is a diuretic and acts directly on the kidneys to promote the removal of salts and water from the blood, which increase the urine volume and decreases blood volume. The combined action of Losartan and hydrochlorothiazide provides a significant and additive reduction in blood pressure, which is maintained for as long as you take your Hyzaar tablets.
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